Soluble mesothelin-related protein--a blood test for mesothelioma.
Title
Soluble mesothelin-related protein--a blood test for mesothelioma.
Source
Lung Cancer. 49 Suppl 1:S109-11, 2005 Jul.
Lung Cancer. 49 Suppl 1:S109-11, 2005 Jul.
Identification of tumor marker for mesothelioma (MM) might prove useful in diagnosis as well as for monitoring tumor in response to therapy and for screening at-risk individuals. We tested the hypothesis that soluble mesothelin-related protein (SMRP), a mesothelin family member, in the serum would be such a marker. Our data show that determination of SMRP in serum is a marker of MM with a sensitivity of sensitivity 83% and specificity 95% in the first 48 MM patients tested.
Changes in serum SMRP levels parallel clinical course/tumor size and SMRP is elevated in 75% of patients at diagnosis. SMRP should also be useful for monitoring disease progression, and importantly, may prove useful for screening asbestos-exposed individuals for early MM.
posted by my-healthcare at 7:50 AM
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