Mesothelioma : Extrathoracic mesothelial proliferations and their mimics.

Title
Extrathoracic mesothelial proliferations and their mimics.

Source
Ultrastructural Pathology. 30(1):37-51, 2006 Jan-Feb.

Mesothelial proliferations, either reactive or neoplastic in nature, often pose difficult diagnostic dilemmas. Electron microscopy continues to be a gold standard in the identification of mesothelial differentiation. However, it is very common to apply long panels of antibodies for that purpose. In most cases, light microscopy and immunohistochemistry will solve the problem. However, the definitive, specific, and sensitive immunohistochemical marker is still lacking. This is particularly true in peritoneal and testicular mesothelial tumors, in which common embryologic origin with epithelial elements results in overlapping immunohistochemistry and morphology.